The rapid escalation in the global prevalence diabetes, with more than 30% being afflicted with diabetic retinopathy
(DR), means it is likely that associated vision-threatening conditions will also rise substantially. This means that
new therapeutic approaches need to be found that go beyond the current standards of diabetic care, and which are effective
in the early stages of the disease. In recent decades several new pharmacological agents have been investigated for their
effectiveness in preventing the appearance and progression of DR or in reversing DR; some with limited success while
others appear promising. This up-to-date critical review of non-traditional systemic treatments for DR is based on the published
evidence in MEDLINE spanning 1980-December 2014. It discusses a number of therapeutic options, paying particular
attention to the mechanisms of action and the clinical evidence for the use of renin-angiotensin system blockade,
fenofibrate and calcium dobesilate monohydrate in DR.
Keywords: Calcium dobesilate, diabetic retinopathy, fenofibrate, renin-angiotensin system blockade.
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