In recent years, low vitamin D status has been proposed as a putative risk factor for allergic
diseases. A growing body of literature reports low vitamin D levels in atopic patients and supports an
association between vitamin D deficiency and risk of adverse asthma and allergies outcomes.
Therefore, it has been speculated that vitamin D supplementation may either prevent or reduce the risk
of allergic diseases. Birth cohort studies addressing the role of vitamin D intake during pregnancy
have shown conflicting results regarding allergy outcomes in offspring. Currently, only a few studies
have tried to supplement vitamin D in asthmatic patients, often as an add-on therapy to standard asthma controller
medications, and results are not all consistent. There is emerging data to show that vitamin D can enhance the antiinflammatory
effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant asthma. Recent in
vivo data suggest that vitamin D supplementation may also reduce the severity of atopic dermatitis. This review examines
the existing relevant literature focusing on vitamin D supplementation in the treatment of allergic diseases.
Keywords: Allergy, asthma, atopic dermatitis, food allergy, therapy, vitamin D.
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