Biological and Pharmacological Activities of 1,3,4-Thiadiazole Based Compounds

Author(s): Joanna Matysiak

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 9 , 2015

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The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles includes the cyclization of appropriate linear organic derivatives. They are widely known as compounds with various kinds of biological activities showing anticancer properties against human cancers and acting as diuretic, antibacterial, antifungal, antitubercular and leishmanicidal agents. Many of them influence on OUN exhibiting anticonvulsant, anti-inflammatory, antidepressant, analgesic and anxiolytic effects. The molecular target of 1,3,4-thiadiazoles includes the following enzymes: carbonic anhydrase (CA), cyclooxygenase (CO), neutral endopeptidase (NEP), aminopeptidase N (APN), matrix metalloproteinases (MMPs), phosphodiesterases (PDEs) and c-Src/Abl tyrosine kinase. In this presentation, recent achievements in the medicinal chemistry of 1,3,4-thiadiazole based compounds are reviewed.

Keywords: Anticancer agents, anticonvulsant activity, carbonic anhydrase inhibitors, cyclooxygenase inhibitors, diuretics, leishmanicidal agents, metalloproteinases inhibitors, 1, 3, 4-thiadiazoles.

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Article Details

Year: 2015
Published on: 24 May, 2015
Page: [762 - 775]
Pages: 14
DOI: 10.2174/1389557515666150519104057
Price: $65

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