1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic
approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly
sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a
catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement.
In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles
through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires
Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.
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