Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets

Author(s): Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa, Ikuo Kimura

Journal Name: Current Drug Targets

Volume 17 , Issue 10 , 2016

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Abstract:

Progesterone receptor membrane components 1 and 2, neudesin, and neuferricin belong to the membraneassociated progesterone receptor (MAPR) family. Recently, sex steroid membrane receptors have gained attention because of their potential involvement in sex hormone-mediated rapid non-genomic effects, which cannot currently be explained by the genomic action of nuclear receptors. Progesterone may increase cell proliferation and survival via nongenomic effects including the activation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3- kinase (PI3K) pathways through MAPRs. Moreover, the unique expression of MAPRs suggests that they could be used as biomarkers and drug targets for sex steroid-related cancers and other diseases. In this review, we summarize the physiological roles of the MAPRs, provide a comprehensive overview of their progesterone-mediated non-genomic actions, and discuss new insights into their potential as therapeutic targets.

Keywords: Progesterone, PGRMC1, PGRMC2, neudesin, neuferricin, cancer.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2016
Page: [1189 - 1197]
Pages: 9
DOI: 10.2174/1389450116666150518102651
Price: $65

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