A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth

Author(s): Ting-Yuan Tseng, Cheng-Chung Chang, Jing-Jer Lin, Ta-Chau Chang

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 19 , 2015

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Graphical Abstract:


Compelling evidence suggests that formation of guanine-quadruplex (G4) can protect the integrity of chromosome ends in eukaryotes, and regulate the activity of some gene promoters. In addition, G4 may be a novel therapeutic target. Thus, a number of ligands have been synthesized to stabilize G4. However, skepticism lingers over the existence of G4 in cells, as well as its biological function. The molecule 3,6-bis(1-methyl-4-vinylpyridium) carbazole diiodide (BMVC) can be used not only as a fluorescent probe to map endogenous and exogenous G4 in live cells, but also as therapeutic agent that arrests cancer growth by inhibiting telomerase activity and regulating gene expression. Thus, the fluorescence of a G4 anti-cancer agent is an invaluable tool to detect G4 in cells, investigate ligand-G4 interaction in live cells, examine the biological function of G4, and guide the development of new fluorescent anti-cancer agents.

Keywords: BMVC, G-quadruplex , Fluorescent anti-cancer agent, Fluorescent image.

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Article Details

Year: 2015
Published on: 24 June, 2015
Page: [1964 - 1970]
Pages: 7
DOI: 10.2174/1568026615666150515150412
Price: $65

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