Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

Author(s): Jessica Kele Arruda Macedo, Jay W. Fox, Mariana de Souza Castro

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 6 , 2015

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability.

Keywords: Antitumor, carcinogenesis, cell death, integrins, metastasis, snake venoms, tumor promotion.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2015
Published on: 15 May, 2015
Page: [532 - 548]
Pages: 17
DOI: 10.2174/1389203716666150515125002

Article Metrics

PDF: 142