Abstract
Iron chelating drugs can impede the rapid reproduction of tumor cells. Among these drugs, deferasirox (DEF) have shown antitumor properties and therefore been selected for this study. The aim of this study was preparation and characterization of the bifunctional polymeric nanoparticles (NPs) by targeting moieties which is applied in cancer.
Therefore, DEF NPs were fabricated by exploiting of PLGA-PEG-FOL conjugate and combination of sonication and emulsification/solvent evaporation technique. Then the influence of important factors including the amount of vitamin E TPGS as a safe surfactant and the ratio of drug to polymer in organic phase was evaluated. Some formulations showed suitable size distribution below 200 nm with high drug entrapment. Drug release study indicated sustained release profile of DEF encapsulated in NPs. Stability study showed acceptable condition for preserving the formulation during six months.
Keywords: Bifunction, deferasirox, drug delivery, nanotechnology, PLGA-PEG-folate.
Nanoscience & Nanotechnology-Asia
Title:Preparation and Characterization of Bifunctional Nanoparticles of Vitamin E TPGS-emulsified PLGA-PEG-FOL Containing Deferasirox
Volume: 4 Issue: 2
Author(s): Mina Mir and Pedram Ebrahimnejad
Affiliation:
Keywords: Bifunction, deferasirox, drug delivery, nanotechnology, PLGA-PEG-folate.
Abstract: Iron chelating drugs can impede the rapid reproduction of tumor cells. Among these drugs, deferasirox (DEF) have shown antitumor properties and therefore been selected for this study. The aim of this study was preparation and characterization of the bifunctional polymeric nanoparticles (NPs) by targeting moieties which is applied in cancer.
Therefore, DEF NPs were fabricated by exploiting of PLGA-PEG-FOL conjugate and combination of sonication and emulsification/solvent evaporation technique. Then the influence of important factors including the amount of vitamin E TPGS as a safe surfactant and the ratio of drug to polymer in organic phase was evaluated. Some formulations showed suitable size distribution below 200 nm with high drug entrapment. Drug release study indicated sustained release profile of DEF encapsulated in NPs. Stability study showed acceptable condition for preserving the formulation during six months.
Export Options
About this article
Cite this article as:
Mir Mina and Ebrahimnejad Pedram, Preparation and Characterization of Bifunctional Nanoparticles of Vitamin E TPGS-emulsified PLGA-PEG-FOL Containing Deferasirox, Nanoscience & Nanotechnology-Asia 2014; 4 (2) . https://dx.doi.org/10.2174/2210681205666150515000224
DOI https://dx.doi.org/10.2174/2210681205666150515000224 |
Print ISSN 2210-6812 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-6820 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Obesity and Cancer: Biological Links and Treatment Implications
Current Cancer Drug Targets NGR-based Strategies for Targeting Delivery of Chemotherapeutics to Tumor Vasculature
Anti-Cancer Agents in Medicinal Chemistry Epidemiology and Pathophysiology of Chronic Cough
Current Respiratory Medicine Reviews Heat Shock Proteins as Prognostic Markers of Cancer
Current Cancer Drug Targets Purinergic Receptors and Pain
Current Pharmaceutical Design Latest Results for Anti-Angiogenic Drugs in Cancer Treatment
Current Pharmaceutical Design Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer
Current Medicinal Chemistry PDE5 Inhibitor Treatment Options for Urologic and Non-Urologic Indications: 2012 Update
Current Pharmaceutical Design Non Polymeric Nanoparticles for Photodynamic Therapy Applications: Recent Developments
Current Medicinal Chemistry Potential Health Benefits of Berries
Current Nutrition & Food Science Interactions of Cisplatin with non-DNA Targets and their Influence on Anticancer Activity and Drug Toxicity: The Complex World of the Platinum Complex
Current Cancer Drug Targets Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Current Medicinal Chemistry Application of Nanotechnology in the Treatment and Diagnosis of Gastrointestinal Cancers: Review of Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Critical microRNAs in Lung Cancer: Recent Advances and Potential Applications
Anti-Cancer Agents in Medicinal Chemistry Synthetic 2-Methoxyestradiol Derivatives: Structure-Activity Relationships
Current Medicinal Chemistry The Role and Therapeutic Potential of Ser/Thr Phosphatase PP2A in Apoptotic Signalling Networks in Human Cancer Cells
Current Molecular Medicine Multi-label Learning for the Diagnosis of Cancer and Identification of Novel Biomarkers with High-throughput Omics
Current Bioinformatics Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica
Anti-Cancer Agents in Medicinal Chemistry Non-Analgesic Effects of Opioids: Opioid-induced Nausea and Vomiting: Mechanisms and Strategies for their Limitation
Current Pharmaceutical Design Oral Precancerous Lesions Show Increased Levels of Glutathione Compared to Cancerous Tissue
Current Nutrition & Food Science