Syntheses and Activity of Carbohydrate-Containing Chitinase Inhibitors

Author(s): Gangliang Huang, Xinya Mei, Xin Chen, Xiaomei Wang

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 10 , 2015

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Abstract:

The pseudo-trisaccharide allosamidin 1 is a potent inhibitor of all family 18 chitinases, and it is confirmed to have insecticidal and antifungal activities. However, the synthesis of allosamidins is very difficult, and it is a challengeable subject. Allosamidins were synthesized in solid/liquid phase and total solid phase, respectively. Solid/liquid-phase method realizes the partial solid-phase synthesis of allosamidins. Total solid-phase method greatly simplifies the purification process. Moreover, it indicated that the inhibitory activity of N,N'-diacetyl-β-chitobiosylallosamizoline 9 against chitinase from Bombyx mori was a little weaker than that of allosamidin 1.

Keywords: Allosamidins, solid/liquid-phase synthesis, total solid-phase synthesis, chitinase inhibitory activity, comparison.

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Article Details

VOLUME: 12
ISSUE: 10
Year: 2015
Page: [828 - 832]
Pages: 5
DOI: 10.2174/1570180812666150514234246
Price: $65

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