A series of simple isatin Schiff bases were synthesized through the condensation reaction.
These isatin Schiff bases were characterized by NMR and MS, and the structure was discussed. Then,
the cytoprotective and anti-tumor activities of these compounds were evaluated. The results show that
several compounds show protection activity on the apoptosis of PC12 cells induced by H2O2, which
are more effective than that of (±) α-Tocophreol (VE) and isatin. Besides, some compounds also show
more potent anti-tumor activity against A549 and P388 cell lines than that of isatin.
Keywords: Isatin, synthesis, schiff base, structure, cytoprotective, anti-tumor.
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