Synthesis, Cytoprotective and Anti-Tumor Activities of Isatin Schiff Bases

Author(s): Gang Chen, Mei Meng, Yu Zhang, Xiaojiang Hao, Ye Wang, Shuzhen Mu

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 10 , 2015

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Graphical Abstract:


A series of simple isatin Schiff bases were synthesized through the condensation reaction. These isatin Schiff bases were characterized by NMR and MS, and the structure was discussed. Then, the cytoprotective and anti-tumor activities of these compounds were evaluated. The results show that several compounds show protection activity on the apoptosis of PC12 cells induced by H2O2, which are more effective than that of (±) α-Tocophreol (VE) and isatin. Besides, some compounds also show more potent anti-tumor activity against A549 and P388 cell lines than that of isatin.

Keywords: Isatin, synthesis, schiff base, structure, cytoprotective, anti-tumor.

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Article Details

Year: 2015
Page: [802 - 805]
Pages: 4
DOI: 10.2174/1570180812666150514234029
Price: $65

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