Genomic studies revealed two main components in the genetic architecture of
schizophrenia, one constituted by common variants determining a distributed polygenic effect and one
represented by a large number of heterogeneous rare and highly disruptive mutations. These gene
modifications often affect neural transmission and different studies proved an involvement of
metabotropic glutamate receptors in schizophrenia phenotype. Through the combination of literature
information with genomic data from public repositories, we analyzed the current knowledge on the involvement of genetic
variations of the human metabotropic glutamate receptors in schizophrenia and related endophenotypes. Despite the
analysis did not reveal a definitive connection, different suggestive associations have been identified and in particular a
relevant role has emerged for GRM3 in affecting specific schizophrenia endophenotypes. This supports the hypothesis
that these receptors are directly involved in schizophrenia disorder.
Keywords: Metabotropic glutamate receptors, schizophrenia, antipsychotic drugs, gene variants, omics data, bioinformatics.
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