Clinical Next Generation Sequencing for Precision Medicine in Cancer

Author(s): Ling Dong, Wanheng Wang, Alvin Li, Rina Kansal, Yuhan Chen, Hong Chen, Xinmin Li

Journal Name: Current Genomics

Volume 16 , Issue 4 , 2015

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Graphical Abstract:


Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to do more with less), the NGS technology is becoming a driving force to realize the dream of precision medicine. This article describes the strengths of NGS, NGS panels used in precision medicine, current applications of NGS in cytology, and its challenges and future directions for routine clinical use.

Keywords: Next generation sequencing, Gene panel, Precision medicine, Whole exome sequencing, Cancer.

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Article Details

Year: 2015
Page: [253 - 263]
Pages: 11
DOI: 10.2174/1389202915666150511205313
Price: $65

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PDF: 28