Prevention of Serum Albumin Glycation/Fibrillation by β-Cyclodextrin Functionalized Magnetic Nanoparticles

Author(s): Mojtaba Ansari, Mehran Habibi-Rezaei, Soheila Salahshour-Kordestani, Ali A. Moosavi Movahedi, Najmeh Poursasan

Journal Name: Protein & Peptide Letters

Volume 22 , Issue 7 , 2015


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Abstract:

Nowadays, glycation induced protein aggregation and related opposing strategies have received much attention. We present the effect of functionalized magnetic core–shell nanoparticles of Fe3O4 (MNPs) with β-cyclodextrin (β-CD) on the aggregation/fibrillation of bovine serum albumin (BSA) under diabetic condition known as amyloidogenesis. To confirm the β-CD conjugation on MNP, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) methods were applied. Moreover, spectrofluorimetry and spectropolarimetry were utilized to analyze the effect of β-CD/Fe3O4 MNPs on the aggregation and amyloidogenesis of BSA through glycation. The BSA amyloidogenesis was significantly inhibited by interfering β-CD-MNPs that may present the possible diagnostic and preventive applications against the degenerative effects of protein glycation/fibrillation under diabetes.

Keywords: Aggregation, β-cyclodextrin, diabetes, fibrillation, magnetic nanoparticles.

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Article Details

VOLUME: 22
ISSUE: 7
Year: 2015
Published on: 16 June, 2015
Page: [594 - 600]
Pages: 7
DOI: 10.2174/0929866522666150511150827
Price: $65

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