Nowadays, glycation induced protein aggregation and related opposing strategies have received
much attention. We present the effect of functionalized magnetic core–shell nanoparticles of
Fe3O4 (MNPs) with β-cyclodextrin (β-CD) on the aggregation/fibrillation of bovine serum albumin
(BSA) under diabetic condition known as amyloidogenesis. To confirm the β-CD conjugation on
MNP, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric
analysis (TGA), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) methods were applied.
Moreover, spectrofluorimetry and spectropolarimetry were utilized to analyze the effect of β-CD/Fe3O4 MNPs on
the aggregation and amyloidogenesis of BSA through glycation. The BSA amyloidogenesis was significantly inhibited by
interfering β-CD-MNPs that may present the possible diagnostic and preventive applications against the degenerative effects
of protein glycation/fibrillation under diabetes.