An efficient and environmentally benign diversity oriented synthetic protocol has
been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike
molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles)
have been synthesized by three-component reaction of isatoic anhydride,
aromatic amines and substituted isatins using gluconic acid aqueous solution (GAAS, 50%,
wt%) as an efficient, inexpensive and eco-friendly bio-based catalytic solvent system.
Keywords: Diversity oriented synthesis, environmentally benign synthetic protocol,
spiroquinazoline-spirooxindoles, gluconic acid aqueous solution (GAAS, 50%, wt%).
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