Nano-zinc Coordination with the Ligands of Carboplatin, Oxaliplatin and Nedaplatin. Synthesis, Characterization and Biological Properties

Author(s): Rahebeh Amiri Dehkharghani, Farzaneh Keshtpoor, Hadis Yazdani Niaki

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 7 , 2015

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Abstract:

The replacement of platinum in carboplatin, oxaliplatin and nedaplatin by zinc metal (in bulk and nano-scalled) produces biologically active compounds with increased solubility in water. We compared, in this work, three synthesized zinc-complexes from the ligands of platinum-anticancer drugs. The structural characterization of the products has been determined on the basis of their atomic absorption spectroscopy, elemental analysis, FT-IR, 1H and 13C NMR spectra. The crystalline structure and morphology of the products have been shown by XRD and SEM techniques. The antibacterial activities of the complexes have been examined through the growth inhibitory zone and minimal inhibitory concentrations.

Keywords: Biologically active, carboplatin, nano-scalled ZnO, nedaplatin, oxaliplatin, synthesis, zinc-complexes

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Article Details

VOLUME: 12
ISSUE: 7
Year: 2015
Page: [491 - 496]
Pages: 6
DOI: 10.2174/1570178612666150507223126
Price: $65

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