Clinical Significance of miR-1826 as a Novel Prognostic Biomarker in Colorectal Cancer

Author(s): You Hu, Bin Yi, Songbing He, Ling Gao, Pengfei Liu, Lei Wang, Jing Yu, Daiwei Wan, Jin Zhou, Xinguo Zhu, Qiaoming Zhi

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 16 , Issue 9 , 2016

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Graphical Abstract:


Several reports indicated that aberrant miR-1826 was involved in the initiation and progression of malignancies. However, the clinical significance of miR-1826 in human colorectal cancer (CRC) has not been addressed. The aim of this study was to evaluate the expression and clinical significance of miR-1826 in CRC. We detected miR-1826 expressions by quantitative realtime PCR (qRT-PCR) in 72 CRC tissues, adjacent nontumor tissues (NATs) and five CRC cell lines, and found that miR-1826 expression in CRC tissues was higher than that in NATs (p<0.05). High miR-1826 expression was significantly associated with some clinicopathologic features such as regional lymph node metastasis (p=0.018), advanced TNM clinical stage (p=0.004), which led to a poor overall survival rate in CRC patients (p=0.032). Our further studies in vitro also demonstrated that miR-1826 inhibitor could effectively suppress the cell proliferation, promote apoptosis and induce G0/G1 cell cycle arrest in CRC cells (p<0.05). Meanwhile, the abilities of cell invasion and migration were effectively suppressed by miR-1826 inhibitor (p<0.05). These findings strongly suggested that miR-1826 played a critical role in the initiation and progression of CRC. Up-regulation of miR-1826 might serve as a novel prognostic marker of CRC and could be a potential target for CRC therapies.

Keywords: Biomarker, colorectal cancer, miR-1826, prognosis.

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Article Details

Year: 2016
Published on: 15 August, 2016
Page: [1109 - 1116]
Pages: 8
DOI: 10.2174/1871520615666150507122434
Price: $65

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