Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

Author(s): Gaetano Santulli, Andrew R. Marks

Journal Name: Current Molecular Pharmacology

Volume 8 , Issue 2 , 2015

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Graphical Abstract:


Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

Keywords: Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.

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Article Details

Year: 2015
Page: [206 - 222]
Pages: 17
DOI: 10.2174/1874467208666150507105105
Price: $65

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