Abstract
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.
Keywords: Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.
Current Molecular Pharmacology
Title:Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging
Volume: 8
Author(s): Gaetano Santulli and Andrew R. Marks
Affiliation:
Keywords: Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.
Abstract: Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.
Export Options
About this article
Cite this article as:
Santulli Gaetano and R. Marks Andrew, Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging, Current Molecular Pharmacology 2015; 8 (2) . https://dx.doi.org/10.2174/1874467208666150507105105
DOI https://dx.doi.org/10.2174/1874467208666150507105105 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Homeostasis and Compensatory Homeostasis: Bridging Western Medicine and Traditional Chinese Medicine
Current Cardiology Reviews Antiproliferative Strategies for the Treatment of Vascular Proliferative Disease
Current Vascular Pharmacology Ubiquitin and ubiquitin-like proteins in cardiac disease and protection
Current Drug Targets Dissections of the Thoracic Aorta and Evolving Endovascular Strategies
Current Hypertension Reviews Sweet and Sour - Oxidative and Carbonyl Stress in Neurological Disorders
CNS & Neurological Disorders - Drug Targets Treating Heart Failure in Older and Oldest Old Patients
Current Pharmaceutical Design Treatment of Inflammatory Diseases with Mesenchymal Stem Cells
Inflammation & Allergy - Drug Targets (Discontinued) Crystallization and Preliminary X-Ray Analysis of the Highly Thermostable Sweet Protein Mabinlin II
Protein & Peptide Letters Targeting Receptor Tyrosine Kinases Using Monoclonal Antibodies: The Most Specific Tools for Targeted-Based Cancer Therapy
Current Drug Targets Bone Disease - Current Knowledge and Future Prospects
Current Genomics Role of Statins in Diabetes Complications
Current Diabetes Reviews Eplerenone, a New Selective Aldosterone Blocker
Current Pharmaceutical Design Understanding Tumor-Antigen Presentation in the New Era of Cancer Immunotherapy
Current Pharmaceutical Design Pexelizumab and its Role in the Treatment of Myocardial Infarction and in Coronary Artery Bypass Graft Surgery: A Review
Recent Patents on Cardiovascular Drug Discovery Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations
Current Molecular Medicine Paving Roads for New Drugs in Oncology
Recent Patents on Anti-Cancer Drug Discovery The Right Ventricle: Biologic Insights and Response to Disease: Updated
Current Cardiology Reviews Interrelationships with Metabolic Syndrome, Obesity and Cardiovascular Risk
Current Vascular Pharmacology Imaging of Organ Metabolism in Obesity and Diabetes: Treatment Perspectives
Current Pharmaceutical Design Pharmacological Management of Diabetes for Reducing Glucose Levels and Cardiovascular Disease Risk: What Evidence in South Asians?
Current Diabetes Reviews