Calcium Channel Signaling Complexes with Receptors and Channels

Author(s): Gerald W. Zamponi

Journal Name: Current Molecular Pharmacology

Volume 8 , Issue 1 , 2015

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Graphical Abstract:


Voltage-gated calcium channels are not only mediators of cell signalling events, but also are recipients of signalling inputs from G protein coupled receptors (GPCRs) and their associated second messenger pathways. The coupling of GPCRs to calcium channels is optimized through the formation of receptor-channel complexes. In addition, this provides a mechanism for receptorchannel co-trafficking to and from the plasma membrane. On the other hand, voltage-gated calcium channel activity affects other types of ion channels such as voltage-and calcium-activated potassium channels. Coupling efficiency between these two families of channels is also enhanced through the formation of channel-channel complexes. This review provides a concise overview of the current state of knowledge on the physical interactions between voltage-gated calcium channels and members of the GPCR family, and with other types of ion channels.

Keywords: Calcium channels, G proteins, receptors, potassium channels, calcium-activated potassium channels, cell signaling.

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Article Details

Year: 2015
Published on: 08 September, 2015
Page: [8 - 11]
Pages: 4
DOI: 10.2174/1874467208666150507093116

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PDF: 110