An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation

Author(s): Monmi Saikia, Dibakar C. Deka, Sanjeeb Karmakar

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016


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Abstract:

An efficient and green protocol for the synthesis of β-aminocarbonyl and β-aminonitrile compounds has been developed. Near quantitative yield is achieved by mixing of a primary or a secondary amine with an α,β-unsaturated carbonyl compound under microwave irradiation in the presence of indium(III) triflate as the catalyst in glycerol as a green solvent. The reaction is simple, clean and complete within a few minutes and the product needs no purification.

Keywords: Aza-michael, glycerol, microwave, β-aminocarbonyl, β-aminonitrile.

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2016
Published on: 05 May, 2015
Page: [47 - 54]
Pages: 8
DOI: 10.2174/2213335602666150505220420

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