Starting from 4-ethylguajacol in only 3–4 steps the new photolabile protecting group (PPG) precursors
AMNPPol and AMNPPOCOCl can be obtained, which are suitable for the protection of the N- and the C-terminus
of amino acids and peptides. The incorporated allyl functionality allows subsequent ring closing reactions with
other unsaturations in the peptide. These protecting groups can be removed faster than the commonly used (substituted)
nitrobenzyl protecting groups.
Keywords: Amino acids, peptides, photolabile protecting groups, protecting groups, ring closing metathesis.
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