Title:Lower Uric Acid Linked with Cognitive Dysfunction in the Elderly
VOLUME: 14 ISSUE: 5
Author(s):Edna Mendez-Hernandez, Jose Salas-Pacheco, Luis Ruano-Calderon, Alfredo Tellez-Valencia, Jorge Cisneros-Martinez, Marcelo Barraza-Salas and Oscar Arias-Carrion
Affiliation:Hospital General Dr. Manuel Gea Gonzalez, Unidad de Trastornos del Movimiento y Sueno (TMS), Mexico City, Mexico.
Keywords:Cardiovascular risk factors, cognitive dysfunction, dementia, elderly, serum uric acid.
Abstract:Uric acid has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence
that uric acid plays a role as antioxidant in the brain. In cognitive dysfunction, vascular and oxidative stress mechanisms play a
role, but the link remains unknown. Therefore, we investigated the link between serum uric acid-levels and cognitive function in
62 elderly subjects. The statistical analysis was adjusted to age, sex and cardiovascular risk factors. Here, we found that lower
serum uric acid levels are linked to cognitive dysfunction. In a Mexican population, higher levels of uric acid are associated with
a decreased risk of dementia.
