The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)-
2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of
K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based
polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using
IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate
Keywords: Polyhydroquinoline, 2, 4-Dichloroquinolines, regioselectivity, in-silico analysis, P. falciparum lactate dehydrogenase.
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