Title:The Efficacies and Toxicities of Antidepressant Drugs in Clinics, Building the Relationship between Chemo-Genetics and Socio-Environments
VOLUME: 16 ISSUE: 1
Author(s):Da-Yong Lu, Ting-Ren Lu, Peng-Peng Zhu and Jin-Yu Che
Affiliation:Shanghai University, Shanghai 200444, P.R. China.
Keywords:Drug response, drug risk, genetics, human genome, medicinal chemistry, neural toxicity, next generation sequencing.
Abstract:Antidepressants generally relief human depressive symptoms and help depressed people.
Nevertheless, some undesired clinical events, such as suicide have been emerging more recently. In
order to improve and promote antidepressant utilizations in clinics, new researches are focusing on reevaluation
of the relationship between efficacy and toxicities of antidepressants in China and US.
These researches speed up quickly. Many creative ideas and discoveries have been made, including
predictions of the efficacies and toxicities of antidepressants under the same evaluating systems
(pharmacogenetics and bioinformatics), genome-wide associate study (GWAS) of the relationship between
individual genetic factors and therapeutic outcomes of different types of antidepressants and socio-environmental
factors. Hopefully, therapeutic efficacies and outcomes by different types of antidepressant treatments for patients can be
improved in clinical trials in the near future.
