Title:Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum
VOLUME: 11 ISSUE: 7
Author(s):Jabrane Azelmat, Serena Fiorito, Salvatore Genovese, Francesco Epifano and Daniel Grenier
Affiliation:Groupe de Recherche en Ecologie Buccale (GREB), Faculte de Medecine Dentaire, Universite Laval, 2420 Rue de la Terrasse, Quebec City, Quebec, G1V 0A6, Canada.
Keywords:Quinolobactin, antibacterial, anti-inflammatory, periodontal disease.
Abstract:The diisopentenyloxy quinolobactin derivative 3-methylbut-2-enyl-4-methoxy-8-[(3-
methylbut-2-enyl)oxy] quinoline-2-carboxylate, also named as Ppc-1, has been initially isolated from
the fruiting bodies of the cellular slime mold Polysphondylium pseudo-candidum. Given that few data
are available in the literature concerning the biological properties of this compound, this study was
undertaken to evaluate its antibacterial and anti-inflammatory properties. Ppc-1 exerted antibacterial
activity on the Gram negative periodontopathogen Porphyromonas gingivalis, while it had no such effect
on the other bacterial species tested. The antibacterial activity of Ppc-1 appeared to result from its ability to permeate
the cell membrane. Using the U937-3xκB-LUC human monocytic cell line, Ppc-1 was found to dose-dependently inhibit
the lipopolysaccharide-induced NF-κB activation, a signaling pathway that has been associated with inflammatory mediator
secretion. In conclusion, Ppc-1, by exhibiting a dual mode of action including antibacterial and anti-inflammatory activities,
may represent a promising targeted therapeutic agent for periodontal diseases.
