High Cytotoxicity and Apoptotic Effects of Natural Bioactive Benzofuran Derivative on the MCF-7 Breast Cancer Cell Line

Author(s): Afsane Soleimani, Jahanbakhsh Asadi, Faramarz Rostami-Charati, Roghaye Gharaei

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 18 , Issue 5 , 2015

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This study was focused on evaluation of the cytotoxicity and apoptotic affects of benzofuran derivative on MCF-7 breast cancer cell line. This effective compound was isolated from the root of Petasites hybridus plant. For experiments, the MCF-7 cells were treated with several concentrations (0-500μM) of 1-(6-hydroxy-2- isopropenyl-1-benzofuran-5-yl)-1-ethanone 1 at different times. In this study, test of neutral red was also employed for cytotoxicity assay and quantity of P53, P21. Bax genes expression was analyzed using Real-Time PCR and ELISA techniques. Results show that compound 1 has cytotoxicity and apoptotic effects on Human breast cancer (Michigan Cancer Foundation-7) MCF-7 cells.

Keywords: Apoptosis, benzofuran derivative, Cytotoxicity, MCF-7 breast cancer cell line, petasites hybridus.

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Article Details

Year: 2015
Published on: 21 July, 2015
Page: [505 - 513]
Pages: 9
DOI: 10.2174/1386207318666150430114815
Price: $65

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