An Insight into Patents of Fluoroquinolone Derivatives

Author(s): Prabodh Chander Sharma, Mona Piplani, Harish Rajak

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 10 , 2015

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Graphical Abstract:


Fluoroquinolones are well known and among most promising nitrogen containing heterocyclic compounds depicting broad spectrum and potent anti-infective activities. Numerous fluoroquinolone derivatives have been found to possess considerable favorable properties such as excellent bioavailability, good tissue penetrability and low toxic effects which attract the extensive research endeavors worldwide. With a better understanding of structure activity relationships of fluoroquinolones, it has been possible to develop superior compounds. This paper is an attempt to review the recent patents on these drugs with special emphasis on ciprofloxacin, norfloxacin, ofloxacin and moxifloxacin.

Keywords: Antiinfectives, fluoroquinolones, infection, microbes, patents, pharmacokinetics.

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Article Details

Year: 2015
Page: [844 - 855]
Pages: 12
DOI: 10.2174/1570180812666150429234635
Price: $65

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PDF: 27