Molecular Pockets, Umbrellas and Quasi Podands from Steroids: Synthesis, Structure and Applications

Author(s): Tomasz Pospieszny

Journal Name: Mini-Reviews in Organic Chemistry

Volume 12 , Issue 3 , 2015

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Abstract:

A new methods for the synthesis of molecular pockets, molecular umbrellas as well as quasi podands of steroids derivatives have been described. Moreover, a molecular umbrellas and pockets derived from biogenic precursors and their applications are described. Intermolecular 1,3- dipolar cycloaddition gave a quasi podands with 1,2,3-triazole rings. The structures of the products were confirmed by spectral analysis, mass spectrometry and PM5 semiempirical methods. Estimation of the pharmacotherapeutic potential of synthesized compounds has been accomplished on the basis of Prediction of Activity Spectra for Substances (PASS).

Keywords: Bile acids, molecular pockets, molecular umbrellas, PASS, PM5, quasi podands, sterols.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2015
Page: [258 - 270]
Pages: 13
DOI: 10.2174/1570193X1203150429105154
Price: $65

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