Abstract
Due to the progressive decline in smoking and drinking, incidences of head and neck cancers have decreased markedly in the USA and European countries. However, incidences of oropharyngeal cancer (OPC) are rising worldwide in both nonsmokers and nondrinkers. Epidemiologic studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development.
While HPV-associated oropharyngeal carcinoma is characterized by locally advanced disease and poorly differentiated histology, HPV-associated OPC is identified with effective prognosis by reason of its positive response to chemotherapy and radiation. Nevertheless, clinicians need to be aware of the risk of OPC in young people in order to avoid unnecessary delays in diagnosis and treatment.
Interviews with attention to obtaining information including the patient’s history of oral sex can aid in establishing a precise diagnoses in young patients with enlarged neck nodes and/or tonsillar masses.
Keywords: Epidemiology, HPV associated oropharyngeal carcinoma, human papillomavirus (HPV), oropharyngeal carcinoma, prevention, vaccination.
Current Cancer Therapy Reviews
Title:Rapidly Increasing Trends in Oropharyngeal Carcinoma Assessed by Worldwide Epidemiologic Analysis
Volume: 11 Issue: 1
Author(s): Enyinnaya Ofo and Junkichi Yokoyama
Affiliation:
Keywords: Epidemiology, HPV associated oropharyngeal carcinoma, human papillomavirus (HPV), oropharyngeal carcinoma, prevention, vaccination.
Abstract: Due to the progressive decline in smoking and drinking, incidences of head and neck cancers have decreased markedly in the USA and European countries. However, incidences of oropharyngeal cancer (OPC) are rising worldwide in both nonsmokers and nondrinkers. Epidemiologic studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development.
While HPV-associated oropharyngeal carcinoma is characterized by locally advanced disease and poorly differentiated histology, HPV-associated OPC is identified with effective prognosis by reason of its positive response to chemotherapy and radiation. Nevertheless, clinicians need to be aware of the risk of OPC in young people in order to avoid unnecessary delays in diagnosis and treatment.
Interviews with attention to obtaining information including the patient’s history of oral sex can aid in establishing a precise diagnoses in young patients with enlarged neck nodes and/or tonsillar masses.
Export Options
About this article
Cite this article as:
Ofo Enyinnaya and Yokoyama Junkichi, Rapidly Increasing Trends in Oropharyngeal Carcinoma Assessed by Worldwide Epidemiologic Analysis, Current Cancer Therapy Reviews 2015; 11 (1) . https://dx.doi.org/10.2174/1573394711666150428003039
DOI https://dx.doi.org/10.2174/1573394711666150428003039 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics
Current Topics in Medicinal Chemistry Voltage-Dependent Potassium Channels Kv1.3 and Kv1.5 in Human Cancer
Current Cancer Drug Targets Proline-Directed Protein Kinase FA as a Potential Target for Diagnosis and Therapy of Human Cancers
Current Cancer Drug Targets Defensins and Other Biocidal Proteins from Bean Seeds with Medicinal Activities
Current Medicinal Chemistry Molecular and Cellular Regulators of Cancer Angiogenesis
Current Cancer Drug Targets Editorial [Hot Topic: Vaccines and Immunity (Executive Editor: Ted M. Ross)]
Current Pharmaceutical Design Anti-Cancer Therapy: Targeting the Mevalonate Pathway
Current Cancer Drug Targets Minimally Invasive Approach to Endometrial Cancer: Robotics and Laparoscopy
Current Women`s Health Reviews Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells
Anti-Cancer Agents in Medicinal Chemistry Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5- hydroxybenzofurans as a New Class of Antitubulin Agents
Medicinal Chemistry Stable Gastric Pentadecapeptide BPC 157-NO-system Relation
Current Pharmaceutical Design Applications of Solid-State Fermentation Process in Biological Detoxification of Industrial Wastes
Current Biochemical Engineering (Discontinued) Chemopreventive and Anti-leukemic Effects of Ethanol Extracts of Moringa oleifera Leaves on Wistar Rats Bearing Benzene Induced Leukemia
Current Pharmaceutical Biotechnology Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets Anti-Cancer, Pharmacokinetic and Biodistribution Studies of Cremophor EL Free Alternative Paclitaxel Formulation
Current Drug Safety Nanocarriers for the Effective Treatment of Cervical Cancer: Research Advancements and Patent Analysis
Recent Patents on Drug Delivery & Formulation Synthesis of pyridyl benzimidazoles encompassing 4-thiazolidinone derivatives as potential antimicrobial agents
Letters in Drug Design & Discovery Targeting Telomerase for Cancer Therapy
Current Cancer Therapy Reviews miR-126 as a Therapeutic Agent for Diabetes Mellitus
Current Pharmaceutical Design