Curcumin, a natural yellow polyphenol, is isolated from the herb Curcuma
longa L. (turmeric), a member of the ginger family. It has been extensively studied due
to their multiple pharmacological properties. Nevertheless, curcumin has disadvantages such as poor water solubility, poor
bioavailability and rapid metabolism, which has prompted the search for analogues that overcome these shortcomings
while maintaining or improving their good pharmacological properties. Among the main curcumin analogues that have
been developed, the heterocyclic curcuminoids show a high interest. In this review, we describe recent progress in the
synthesis and pharmacological properties of new heterocyclic curcumin derivatives. The most recent developments in
anti-cancer, anti-Alzheimer, anti-bacterial and anti-oxidants heterocyclic curcumin derivatives are covered.