Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy

Author(s): K. Pandima Devi, T. Rajavel, G. L. Russo, M. Daglia, S. F. Nabavi, S. M. Nabavi

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 15 , Issue 7 , 2015

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Graphical Abstract:


Nowadays, dietary guidelines acknowledge the therapeutic role of omega-3 polyunsaturated fatty acids, as the most important class of fatty acids, against different human diseases. During the last two decades, the average level of consumption of omega-3 polyunsaturated fatty acids has increased from 0.1 to 0.2 g per day. Omega-3 polyunsaturated fatty acids are a group of long-chain polyunsaturated fatty acids which are identified in different foods such as fatty fish, shellfish, and vegetable oils. A growing body of epidemiological and experimental evidence supports the anticancer effects of omega-3 polyunsaturated fatty acids, which led to the identification of their molecular targets in several cancer models. The present review focuses on the basic evidence supporting the potential applications of omega-3 polyunsaturated fatty acids in cancer therapy.

Keywords: Anticancer, fish oil, molecular targets, omega-3 polyunsaturated fatty acids.

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Article Details

Year: 2015
Page: [888 - 895]
Pages: 8
DOI: 10.2174/1871520615666150424124606
Price: $65

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PDF: 44