Nano Clinoptilolite: Highly Efficient Catalyst for the Synthesis of Chromene Derivatives Under Solvent-Free Conditions

Author(s): Sara Hallajian, Mohammad A. Khalilzadeh, Mahgol Tajbakhsh, Eskandar Alipour, Zahra Safaei

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 18 , Issue 5 , 2015

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An efficient and selective synthesis of substituted chromene derivatives via threecomponent reaction of 4-hydroxycoumarin or 1,3-dicarbonyl compounds, activated acetylenic compounds and N-nucleophiles is described. The reaction was conducted under solvent-free conditions at 70°C using potassium fluoride impregnated on natural zeolite as a cheap and available solid base. The procedure has several advantages involving selectivity, excellent yields and a convenient work-up method.

Keywords: 4-hydroxycoumarin, acetylenic compounds, N-nucleophiles, solvent-free.

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Article Details

Year: 2015
Published on: 23 April, 2015
Page: [486 - 491]
Pages: 6
DOI: 10.2174/1386207318666150424104452
Price: $65

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