Insights into the Role of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Health and Disease

Author(s): Sudip Das, Sreejani Bandopadhyay, Swati Das

Journal Name: Current Chemical Biology

Volume 8 , Issue 3 , 2014

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Graphical Abstract:


Matrix metalloproteinases (MMPs) are family zinc containing calcium dependent enzymes. They can degrade the different components of extracellular matrixin normal as well as in abnormal condition. MMPs have been found in vertebrates, invertebrates and plants. The synthesis, translocation and function of MMPs are mostly associated with different signaling cascades. The functions of MMPs are intricately regulated by its specific endogenous regulators or the inhibitors known as tissue inhibitor of metalloproteinases (TIMPs) in the time of activation and in inhibition. MMPs and TIMPs are involved in the regulation of cell characteristics in normal as well as the state of human morbidity and mortality. There are numerous roles of MMPsin normal physiological processes and that are good. Again, the ugly is the abnormal activity or overexpression of MMPs that has the distinct role in many disease processes. Presently, broad-spectrum synthetic as well as natural MMP inhibitors have been developed or isolated for the treatment of manyfatal diseases and also sometime for managing the critical complications there in. Therefore, the diverse role of all the MMPs and TIMPs cannot be explained precisely in a particular review because of their multidirectional and multifunctional behavior in mammals. This review is a very small effort to delineate some of the progresses not all in a precise manner with an elaborative description of MMPs towards their multifaceted functions in the light of human physiology and pathology concerned.

Keywords: Cancer, diabetes, inflammation, matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), tissue remodeling, wound healing.

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Article Details

Year: 2014
Page: [184 - 214]
Pages: 31
DOI: 10.2174/221279680803150420095017
Price: $25

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