The rationale of this study was to develop a SMEDDS based thermally triggered in situ
gelling intramuscular implant of Rifampicin. The SMEDDS based in situ gelling system composed of
oleic acid, tween 80, ethanol and Poloxamer 188. The physicochemical properties such as morphology
of solution and gel, droplet size distribution, in situ gelling in chicken muscle, phase transition of
SMEDDS at 37 oC and in vitro dissolution were investigated. The results showed the gelation of
formulation at 37 oC and the in vitro drug release data suggest 80% release of the drug at the end of 7 days and it follows
zero order kinetics. The FTIR studies shows absence of interaction between the drug and the excipients and the particle
size analysis suggests a Nano system. From the results it was noted that Poloxamer based in situ gelling systems have a
promising future as a novel drug delivery system for the delivery of BCS class II drugs.
Keywords: In situ gelling, intramuscular administration, poloxamer, pseudo ternary phase diagram, Poloxamer 188, rifampicin,
SMEDDS, sustained release, thermally triggered.
Rights & PermissionsPrintExport