Obesity, hypertension, obesity-related hypertension such as hypertension with diabetes are
growing health problems. Obesity, hypertension and diabetes are important, independent risk factors
for the onset and development of cardiovascular diseases. Hypertension in obesity is characterized by
stimulation of the renin-angiotensin-aldosterone system (RAAS), elevated sympathetic activity,
insulin resistance and selective leptin resistance. It is known that these characteristics, even in
isolation, constitute risk factors for cardiovascular disease onset and progression. Therefore,
pharmacological treatments should be selected based on favourable effects on insulin resistance,
stimulated RAAS and sympathetic nervous systems.