Title:Targeted Drug Delivery for Cardiovascular and Cerebrovascular Diseases
VOLUME: 17 ISSUE: 4
Author(s):Jingjing Luan and Guangxi Zhai
Affiliation:Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China.
Keywords:Cardiovascular and cerebrovascular diseases, pathophysiological changes, passive, active, physicochemical, targeting,
drug delivery, carriers.
Abstract:Cardiovascular and cerebrovascular diseases (CCVD) are a major and increasing health
burden worldwide. Although treatments have been made a certain progress, the development of novel
therapies for patients remains a major research object. There are a lot of drugs against CCVD, but most
of them lack tissue specificity with a short half-life, which seriously limits their extensive clinical application.
Utilization of some pathophysiological changes caused by CCVD, targeted drug distribution
in CCVD patients could be achieved. The current review aims to capture various drug delivery systems
transporting drug specifically to vascular disease, including passive, active and physicochemical
targeted delivery carriers. Their design strategies and mechanisms are described in detail. The present
limitations and future perspective are also discussed.
