Epigenetics in Cystic Fibrosis: Epigenetic Targeting of a Genetic Disease

Author(s): Nualpun Sirinupong, Zhe Yang

Journal Name: Current Drug Targets

Volume 16 , Issue 9 , 2015

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Abstract:

Cystic fibrosis (CF) is a deadly genetic disease that affects the lungs and digestive system. A mutation in the CF transmembrane conductance regulator (CFTR) gene is the cause of the disease. How epigenetics contributes to CFTR expression is still poorly understood. Epigenetics is a mechanism that alters gene expression without changing the underlying DNA sequence. Epigenetic mechanisms include DNA methylation and histone modification. Both mechanisms have been implicated in CFTR gene regulation. Here we review epigenetic regulation of CFTR transcription while discussing potential epigenetic targeting strategies including DNA methyltransferase, histone deacetylase, and histone methyltransferase and demethylase inhibition. Because of the reversibility of epigenetics, targeting epigenetic mechanisms has been an attractive therapeutic approach. However, epigenetic targeting of CF disease is still at its infant stage.

Keywords: CFTR, cystic fibrosis, DNA methylation, epigenetics, histone acetylation, histone methylation.

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2015
Published on: 28 August, 2015
Page: [976 - 987]
Pages: 12
DOI: 10.2174/1389450116666150416114514
Price: $65

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