A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein
kinase A (PKA) by tethering PKA to distinct cellular compartments. Through additional direct proteinprotein
interactions with PKA substrates and other signaling molecules they form multi-protein complexes.
Thereby, AKAPs regulate the access of PKA to its substrates in a temporal and spatial manner
as well as the local crosstalk of cAMP/PKA with other signaling pathways. Due to the increasing information
on their molecular functioning and three-dimensional structures, and their emerging roles in
the development of diseases, AKAPs move into the focus as potential drug targets. Targeting AKAP dependent
protein-protein interactions for interference with local signal processing inside cells potentially allows for the
development of therapeutics with high selectivity and fewer side effects.
Keywords: AKAP, protein-protein interaction, compartmentalized cAMP signaling, peptide, peptidomimetics, PKA, small
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