Pharmacological Interference With Protein-protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease

Author(s): Veronika A. Deák, Enno Klussmann

Journal Name: Current Drug Targets

Volume 17 , Issue 10 , 2016

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Abstract:

A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein kinase A (PKA) by tethering PKA to distinct cellular compartments. Through additional direct proteinprotein interactions with PKA substrates and other signaling molecules they form multi-protein complexes. Thereby, AKAPs regulate the access of PKA to its substrates in a temporal and spatial manner as well as the local crosstalk of cAMP/PKA with other signaling pathways. Due to the increasing information on their molecular functioning and three-dimensional structures, and their emerging roles in the development of diseases, AKAPs move into the focus as potential drug targets. Targeting AKAP dependent protein-protein interactions for interference with local signal processing inside cells potentially allows for the development of therapeutics with high selectivity and fewer side effects.

Keywords: AKAP, protein-protein interaction, compartmentalized cAMP signaling, peptide, peptidomimetics, PKA, small molecules.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2016
Page: [1147 - 1171]
Pages: 25
DOI: 10.2174/1389450116666150416114247
Price: $65

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