Frontiers in Nanomedicine

Volume: 1

Frontiers in Nanomedicine offers an up-to-date understanding of nanomaterials to readers having clinical or biomolecular research interests. Scientists, both aspiring and experienced, will find, in ...
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Non-Viral Nano-Vectors for Nucleic Acid Delivery

Pp. 222-255 (34)

S. R. Simon Ting, Eun Hee Min, Michael B. Cortie, Hung T. Nguyen and Gyorgy Hutvagner


The development of therapeutic nucleic acids has led to new strategies for treating various diseases. Non-viral, synthetic nano-vectors in gene therapy have attracted increasing attention due to their low immunogenicity and low toxicity compared to viral counterparts. Due to the molecular structure of nucleic acids, they are very prone to degradation in pH sensitive biological environments. Therefore, synthetic nano-vehicles for therapeutic delivery, known as ‘nano-vectors’, need to be cleverly designed and engineered to protect and deliver appropriate therapeutic nucleic acids to the targeted sites for action. In this chapter, a brief overview of various types of therapeutic nucleic acids is first provided, followed by analysis of the synthetic nanomaterials under development as delivery systems to carry nucleic acids. The nucleic acid-encapsulated nano-vectors discussed here open a window for a new generation of nanomedicine.


Cancer, chitosan, co-delivery, delivery, dendrimer, gene therapy, gold, inorganic, iron oxide, liposomes, magnetic, nanocarriers, nanoparticles, nano-vectors, nucleic acid, pDNA, polymer, rheumatoid arthritis, silica, siRNA.


Centre for Health Technologies, University of Technology Sydney, PO Box 123, Broadway, NSW 2007, Australia.