Title:Formulation Strategies and Particle Engineering Technologies for Pulmonary Delivery of Biopharmaceuticals
VOLUME: 21 ISSUE: 19
Author(s):Dongmei Cun, Feng Wan and Mingshi Yang
Affiliation:Department of Pharmaceutics, Shenyang Pharmaceutical University, 110016, China; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark;
Keywords:Pulmonary delivery, proteins and peptides, SiRNA, formulation strategy, particle engineering.
Abstract:Biopharmaceuticals including recombinant proteins, monoclonal antibody and nucleic acid based therapeutics
have become more and more important to improve the quality of life of patients. However, the administration
of biopharmaceuticals was mainly limited to parenteral routes and their delivery remains the most significant
challeng to their clinical adoption due to their unfavorable intrinsic physicochemical properties. Among noninvasive
administration routes the lung has been attempted intensively to be an alternative to injection to deliver the
biopharmaceuticals, and has shown to be promising. In this review we discussed the formulation strategies and particle
engineering technologies to improve the efficiency of pulmonary delivery of biopharmaceutical, with a focus
on systemic therapy of pharmaceutical proteins/peptides and local delivery of siRNA via the lung administration.
