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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

One-Pot Syntheses of 1H-Pyrazolo[1,2-B]Phthalazine-5,10-Diones and 2-H-Indazolo[2,1-B]Phthalazine-1,6,11(13-H)-Triones in Water by Auto Catalysis

Author(s): Y. Dathu Reddy, P. Praveen Kumar, B. Rama Devi, Venkata Ramana Reddy and P. K. Dubey

Volume 12, Issue 6, 2015

Page: [379 - 884] Pages: 506

DOI: 10.2174/1570178612666150415235453

Price: $65

Abstract

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1) , hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water for 1-1.5 h by in-situ generation of HCl as a catalyst. These reactions have an easy workup, provide excellent yields, and use water as the solvent.

Keywords: Water, phthaloyl dichloride, one-pot syntheses, green syntheses.

Graphical Abstract

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