Active Targeted Drug Delivery for Microbes Using Nano-Carriers

Author(s): Yung-Sheng Lin, Ming-Yuan Lee, Chih-Hui Yang, Keng-Shiang Huang

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 15 , 2015

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Graphical Abstract:


Although vaccines and antibiotics could kill or inhibit microbes, many infectious diseases remain difficult to treat because of acquired resistance and adverse side effects. Nano-carriers-based technology has made significant progress for a long time and is introducing a new paradigm in drug delivery. However, it still has some challenges like lack of specificity toward targeting the infectious site. Nanocarriers utilized targeting ligands on their surface called ‘active target’ provide the promising way to solve the problems like accelerating drug delivery to infectious areas and preventing toxicity or sideeffects. In this mini review, we demonstrate the recent studies using the active targeted strategy to kill or inhibit microbes. The four common nano-carriers (e.g. liposomes, nanoparticles, dendrimers and carbon nanotubes) delivering encapsulated drugs are introduced.

Keywords: Active target, Ligands, Microbe, Nano-carrier.

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Article Details

Year: 2015
Page: [1525 - 1531]
Pages: 7
DOI: 10.2174/1568026615666150414123157

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