Nearly all antibiotics are ineffective to the antibiotic-resistant bacteria New Delhi
metallo-beta -lactamase-1(NDM-1), one of the most important reasons is that antibiotics can
be hydrolyzed by NDM-1 in these bacteria. Up to date, Many compounds, including captopril,
are found to possess NDM-1 inhibition activity. Herein we report that some cysteine
derivatives or homocysteine derivatives can inhibit the NDM-1 protein, and the lead compound
9 has the inhibition of the NDM-1 protein with IC50 of 1 µM, which is about 8 times potency of captopril.
Keywords: IC50, NDM-1, cysteine, captopril, derivatives, inhibition.
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