A series 3/4-bromo-N'-(substituted benzylidene/furan-2-ylmethylene/5-oxopentylidene/3-
phenylallylidene)benzohydrazides (1-23) was synthesized and characterized by physicochemical and
spectral means. The synthesized compounds were screened for their antimicrobial and anticancer potentials.
Antimicrobial activity results indicated that compound 12 (pMICam = 1.67 μM/ml) was the
most potent antimicrobial agent. The synthesized benzohydrazides were also having good anticancer potential and compound
22 (IC50 = 1.20 μM μM) was found to be the most potent anticancer agent which was more potent than standard
drugs, tetrandrine (IC50 = 1.53) and 5- fluorouracil (IC50 = 4.6 μM). QSAR studies indicated that antimicrobial activity of
synthesized compounds was best described by electronic parameter, total energy (Te) and topological parameters, valance zero
order molecular connectivity index (0χv) and Wiener index (W).
Keywords: Anticancer activity, Antimicrobial activity, Benzohydrazides, Minimum bactericidal/fungicidal concentration,
Minimum inhibitory concentration, QSAR studies.
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