Title:Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation
VOLUME: 16 ISSUE: 11
Author(s):Hans Hendrik Schafer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna
Affiliation:Kaiser F. Hoffmann-La Roche Ltd, Diagnostics Division, Divisional Medical and Scientific Affairs, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Keywords:Corticosteroid-steroid binding, drug, glucocorticoids, heart, humans, mineralocorticoids.
Abstract:Corticosteroid (glucocorticoids [GCs] and mineralcorticoids [MCs]) interact directly with
cells of the cardiovascular system. Their signaling affects genomic and non-genomic receptors and
comprises a multitude of alternative and interfering levels of interaction, which influence the physiological
response. This review describes genomic and non-genomic pathways of steroid facilitation and
portrays the current body of knowledge regarding corticosteroid-binding globulin (CBG). The latter is
a carrier protein facilitating corticosteroid availability in the circulation and has recently been discovered intrinsically in
cardiomyocytes. Thought experiments highlight potential areas of clinical research and hypotheses are presented for steroid-
carrier interaction. Furthermore, this review comprises a conclusive overview of disease conditions and substances
that influence CBG levels and summarizes the potential of CBG as a potential future biomarker.
