The field of metabolomics has continued to expand rapidly in the past two years. It has become
an important part of personalized, predictive, preventive, and participatory (P4) medicine. In this
article, recent advances in analytical methods (capillary electrophoresis, gas chromatography, liquid
chromatography, mass spectrometry and MS imaging) are described. Advances in data analysis, quality
control and receiver operator characteristic (ROC) curves are also described. The recent uses of
metabolomics in disease diagnosis, epidemiology, epigenetics, hypertension, cancer, toxicology, drug
discovery and the understanding of biological processes are also presented.