Title:Preparation, characterization and <i>in vitro</i> release of zein-pectin capsules for target delivery
VOLUME: 12 ISSUE: 4
Author(s):Wai-Wa Tang, Fangyuan Dong, Ka-Hing Wong and Yi Wang
Affiliation:Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Keywords:Capsule, controlled release, colon-specific drug delivery, pectin, zein.
Abstract:Targeted drug delivery has been the interest of many researchers to improve drug efficiency
and reduce side effects. Because of the potential toxicity and contamination problems of the current
gelatin capsules, plant derived materials are selected for the developments of capsules for drug delivery
systems. The objective of this work is to develop a target drug delivery system using zein and pectin.
Different ratios of zein and pectin were used to achieve target delivery in stomach and small intestine.
Zein-pectin capsule for colon-specific delivery was also developed. In vitro performance of zeinpectin
capsules was examined and their structural morphology was characterized using scanning electron microscopy
(SEM). Chemical interactions between zein and pectin were analyzed using Fourier transform infrared spectroscopy
equipped with attenuated total reflectance (FTIR-ATR). Zein and pectin formed complex by hydrogen bonding. The swelling
behavior of pectin was suppressed by zein in the zein-pectin interacted complex. By adjusting the ratio of zein to pectin,
the drug release from the capsule in simulated gastric solution for 2 hours can be controlled in the range of 0% to
38%. Zein-pectin capsule for colon-specific delivery had no release in gastric and intestinal solutions while gradual release
from zein-pectin capsule was observed in colonic solution, finally reaching about 80% release. Zein-pectin capsule
has a potential in developing targeted drug delivery system.
