Previous studies demonstrated that some pyrazole derivatives could be considered as potential
anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction
of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure.
The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as
well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent
compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous
and normal cell lines.
Keywords: Tri-arylpyrazole, cytotoxicity, synthesis, HT-29, MCF-7, AGS.
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