A convenient one-pot, multi-component and solvent free procedure for the preparation of
substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement
over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and
isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives
in high yields with high purity. All synthesized compounds were characterized by FT-IR,
proton and carbon NMR, mass spectroscopy and elemental analysis. A possible mechanism is proposed
for the cyclodesulfurization based on the results of this study.
Keywords: Catalyst free one pot reaction, microwave irradiation, multi component reaction, oxadiazole, solvent.
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