Abstract
A convenient one-pot, multi-component and solvent free procedure for the preparation of substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives in high yields with high purity. All synthesized compounds were characterized by FT-IR, proton and carbon NMR, mass spectroscopy and elemental analysis. A possible mechanism is proposed for the cyclodesulfurization based on the results of this study.
Keywords: Catalyst free one pot reaction, microwave irradiation, multi component reaction, oxadiazole, solvent.
Current Microwave Chemistry
Title:A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation
Volume: 3 Issue: 1
Author(s): Kinjal D. Patel, Rajesh H. Vekariya and Hitesh D. Patel
Affiliation:
Keywords: Catalyst free one pot reaction, microwave irradiation, multi component reaction, oxadiazole, solvent.
Abstract: A convenient one-pot, multi-component and solvent free procedure for the preparation of substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives in high yields with high purity. All synthesized compounds were characterized by FT-IR, proton and carbon NMR, mass spectroscopy and elemental analysis. A possible mechanism is proposed for the cyclodesulfurization based on the results of this study.
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Cite this article as:
Patel D. Kinjal, Vekariya H. Rajesh and Patel D. Hitesh, A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150324233632
DOI https://dx.doi.org/10.2174/2213335602666150324233632 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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